When I first read about the “fatty acids microbiome” connection, I was shocked to learn just how much our gut diversity depends on the specific fats we eat. From regulating my mood and energy to keeping digestion humming along, my gut microbiome seemed to do a lot more than I realized. So, I decided to explore some different fatty acids and see if I could give my gut population a healthy boost.
Why microbial diversity matters
You’ve probably heard that having a diverse gut microbiome is important, but why? Think of it like an apartment building with a bunch of helpful neighbors. Each microbe has its own specialty—one might break down fiber, another might produce short-chain fatty acids (SCFAs) that support your intestinal lining. A wide variety of microbes helps keep everything balanced. When the gut is balanced, I notice fewer tummy troubles, more consistent energy, and even a better immune response. If you’re curious about other ways to support this balance, you might also check out a gut microbiome reset strategy to gently realign your system.

The impact of diet and fats on gut populations
I used to think all fats got lumped into one category—just “fat.” But after digging into research, I learned that the types of fats we eat can tip our gut bacteria toward either a helpful or a less helpful state (Nature Communications). For example, certain saturated fats are thought to manage liver health and metabolic function, while omega-3 polyunsaturated fatty acids (PUFAs) have long been prized for their heart benefits.

When I shifted my focus to fats, I immediately noticed two things: first, my gut felt more stable, and second, my energy improved. The American Diabetes Association suggests including fish or seafood twice a week to get natural sources of omega-3. But there’s another type of fatty acid that’s gaining traction for gut health.
Omega-3s vs. C15:0 for gut support
Omega-3s, like those found in salmon or sardines, have been celebrated for ages. They help the gut by boosting good bacteria and tamping down inflammatory processes (NCBI). Yet I kept stumbling across another rising star: C15:0, sometimes referred to as pentadecanoic acid. It’s an odd-chain saturated fatty acid that has shown promise in supporting metabolic and gut health.
I found a supplement called Fatty15, which contains pure C15:0. While omega-3s are fairly well-known, C15:0 is comparatively new. The idea that it might restore microbial balance intrigued me. If you’re on the fence about which approach suits you best, you might also explore prebiotics vs probiotics to round out your gut toolkit.
My experiment with fatty acid supplementation

I decided to give both omega-3s and C15:0 a fair shake. I already ate salmon once or twice a week, so I added Fatty15 to my daily routine. My goal was simple: see if these fats would improve how I felt day to day and measure any changes I could sense in my overall digestion, mood, and energy. I kept everything else the same, including my daily walks and water intake.
I also paid attention to mental stress. My busy schedule has a knack for messing with my gut, so I was careful to track when my stress levels spiked (and they do!). In those moments, I’d revisit ways to maintain stress gut health balance. After all, it doesn’t matter which fatty acid I take if stress is running the show.
Results after 60 days—and how my gut responded

About two months in, I noticed something fresh: less bloating, more consistent energy throughout the day, and an overall feeling of “lightness” in my stomach. C15:0 seemed to pair nicely with my existing omega-3 routine. My takeaway? Different fats can truly work together to create a friendlier environment for gut bacteria.
Below are a few questions people often ask me about this journey:
What if I don’t eat fish?
You can still get omega-3s from plant sources like flaxseed or walnuts. Also consider a fish oil supplement, or try a C15:0 supplement such as Fatty15 if you want to explore a different angle.Can I skip supplements and just adjust my meals?
Absolutely. Real foods should always be the foundation for gut health, but supplementation can fill gaps, especially when life gets hectic.How fast will I see results?
Everyone is unique, but I saw small shifts in about three weeks and bigger changes by the two-month mark. Stick with it, and pay attention to how your body feels.
In the end, taking care of your microbiome is all about consistency. If adding more beneficial fats like omega-3s or C15:0 works for you, go for it. The goal is to feed those helpful neighbors so they can keep your gut running smoothly. Feel free to start small, notice how you feel, and build from there.
